in my own experience, it seems to depend what you want your feed to look like. Account central gives you a Twitter like feed of every individual account you follow, whereas something like Lemmy is going to be focused on following communities as a whole.

Personally I use mastodon and subscribe to the lemmy communities I’m interested in seeing in my account-centered feed, good middle ground to get both in one place

All depends on what you're looking to get out of it. I've been quite happy with Friendica but it took me trying ~10 other things to learn that. I landed on it because it gave me the most compatibility with other fediverse things. Hubzilla or Streams are two others that offer even more compatibility but I haven't yet gotten comfortable enough with either to make a decision. Everything has slightly different features to offer, so I'd recommend give em all a ride. The main base models are going to be Mastodon, Pleroma, and Misskey. Each of those have a handful of forks to look at as well. If you're looking to self-host any of them, none are overly difficult as far as I understand.

These pages should provide you with more info than you probably want on em all.

fedidb.org
jointhefediverse.net
fediverse.observer
fediverse.info
fediverse.party